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Zhonghua Nan Ke Xue. 2003 Nov;9(8):566-8.

[Effects of daidzein on sperm quality, testis gain and testosterone in mice].

[Article in Chinese]

Author information

1
College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China.

Abstract

OBJECTIVE:

To evaluate the effects of daidzein on sperm quality of male mice.

METHODS:

Three different doses of daidzein were supplemented to pubertal male mice for 21 days(5 mg/kg, 100 mg/kg, 1,000 mg/kg ration). The viability of sperm was determined by eosin-Y, the acrosome was observed by Wright-Giemsa staining, and the testosterone was measured by radioimmunoassay.

RESULTS:

Daidzein at the dose of 5 mg/kg ration significantly increased serum testosterone levels (P < 0.01), prompted testis gain (P < 0.05), and improved spermatozoa quality. Daidzein at dose of 1,000 mg/kg ration could inhibit the secretion of serum testosterone (P < 0.01), without significant variation in spermatozoa quality. Daidzein at dose of 100 mg/kg ration did not significantly affect sperm quality and other index.

CONCLUSIONS:

Daidzein can affect sperm quality and in dosage-dependant ways.

PMID:
14689883
[Indexed for MEDLINE]

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