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Int J Epidemiol. 1992 Oct;21(5):1014-20.

The measurement and interpretation of age-specific vaccine efficacy.

Author information

1
Communicable Disease Surveillance Centre, London, UK.

Abstract

The age-specific efficacy of a vaccine depends upon the mechanism of vaccine action and the force of infection in the unvaccinated subpopulation. Consequently, inferences concerning the persistence of vaccine-induced immunity cannot in general be made directly from age-specific vaccine efficacy estimates. The definition, estimation and interpretation of age-specific vaccine efficacy measures are discussed using simple models of vaccine action. The methods are applied to data on measles and pertussis vaccines.

PMID:
1468838
DOI:
10.1093/ije/21.5.1014
[Indexed for MEDLINE]

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