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J Neurosci Methods. 2004 Jan 15;132(1):1-7.

A method for peripheral chromatolysis in neurons of trigeminal and dorsal root ganglia, produced in rats by lithium.

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  • 1Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.


In classical chromatolysis, Nissl bodies are initially lost centrally with subsequent progression to the periphery of the neuron. Peripheral chromatolysis has the opposite pattern; it is less common and more difficult to produce. We describe a new method for producing peripheral chromatolysis in neurons of trigeminal ganglia and dorsal root ganglia that requires only injection of large doses of lithium chloride (LiCl) for two, three or four consecutive daily doses. This method may be useful for elucidating the intraneuronal mechanisms that control the location and structure of the Nissl bodies.

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