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Cell Signal. 2004 Mar;16(3):291-9.

Signal transduction of bone morphogenetic protein receptors.

Author information

1
Department of Chemistry, University of Western Ontario, N6A1B7 London, Canada. anohe@uwo.ca

Abstract

Bone morphogenetic proteins (BMPs) play a crucial role during all stages of embryonic development. Although only two major signaling pathways have been characterized (the p38 and Smad pathways), the BMP signaling is complex and includes several negative feedback mechanisms. This article reviews the current state of BMP receptor signaling and provides a summary of the crosstalk of the BMP receptor pathway with other major signaling pathways.

PMID:
14687659
DOI:
10.1016/j.cellsig.2003.08.011
[Indexed for MEDLINE]

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