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FEMS Microbiol Lett. 1992 Nov 15;78(1):59-63.

Cadmium-resistance plasmid in Staphylococcus lugdunensis.

Author information

1
Hôpital Louis Pradel, Laboratoire de Bactériologie, Lyon, France.

Abstract

Plasmids that confer resistance to cadmium (MIC > or = 125 microM), were found in 18 out of 30 independent Staphylococcus lugdunensis strains from clinical specimens. Variants that were cured of their plasmid were cadmium sensitive. Restriction endonuclease sites of a 3.2-kb cadmium-resistance plasmid of S. lugdunensis, designated pLUG10, were similar to those of pOX6, a S. aureus cadmium-resistance plasmid containing the cadB gene. Southern-blot hybridisation was performed with a probe intragenic to cadB. Hybridisation was found with the cadB probe in the cadmium-resistant S. lugdunensis isolates to the 2.9-, 3.2- and 3.7-kb plasmids. These findings suggest that cadmium-resistance in some S. lugdunensis strains is due to a gene sharing homology with the cadB gene of S. aureus.

PMID:
1468617
DOI:
10.1016/0378-1097(92)90288-y
[Indexed for MEDLINE]

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