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Nature. 2003 Dec 18;426(6968):895-9.

Protein degradation and protection against misfolded or damaged proteins.

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Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.


The ultimate mechanism that cells use to ensure the quality of intracellular proteins is the selective destruction of misfolded or damaged polypeptides. In eukaryotic cells, the large ATP-dependent proteolytic machine, the 26S proteasome, prevents the accumulation of non-functional, potentially toxic proteins. This process is of particular importance in protecting cells against harsh conditions (for example, heat shock or oxidative stress) and in a variety of diseases (for example, cystic fibrosis and the major neurodegenerative diseases). A full understanding of the pathogenesis of the protein-folding diseases will require greater knowledge of how misfolded proteins are recognized and selectively degraded.

[Indexed for MEDLINE]

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