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Nature. 2003 Dec 18;426(6968):891-4.

Quality control in the endoplasmic reticulum protein factory.

Author information

1
Università Vita-Salute San Raffaele Scientific Institute, 20132 Milano, Italy. r.sitia@hsr.it

Abstract

The endoplasmic reticulum (ER) is a factory where secretory proteins are manufactured, and where stringent quality-control systems ensure that only correctly folded proteins are sent to their final destinations. The changing needs of the ER factory are monitored by integrated signalling pathways that constantly adjust the levels of folding assistants. ER chaperones and signalling molecules are emerging as drug targets in amyloidoses and other protein-conformational diseases.

PMID:
14685249
DOI:
10.1038/nature02262
[Indexed for MEDLINE]
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