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Bioorg Med Chem Lett. 2004 Jan 5;14(1):161-5.

Synthesis of hydrophilic and flexible linkers for peptide derivatization in solid phase.

Author information

1
Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California-Davis, 4501 X Street, Sacramento, CA 95817, USA.

Abstract

Four N-Fmoc protected polyoxyethylene-based amino acid type linkers were designed and synthesized for peptide derivatization in solid phase. Three of them were obtained in a crystalline form. The crystallized linkers can be stored at 4 degrees C for 2 years without significant decomposition. Protocols for biotinylation and fluorescent labeling of peptides in solid phase were developed. The linkers also provide good ionization ability for single-bead mass spectrometry analysis of peptides.

PMID:
14684320
DOI:
10.1016/j.bmcl.2003.09.067
[Indexed for MEDLINE]

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