Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2004 Jan 5;14(1):55-8.

Discovery of a novel series of DHODH inhibitors by a docking procedure and QSAR refinement.

Author information

1
4SC AG, Am Klopferspitz 19a, 82152 Martinsried, Germany. leban@4sc.com

Abstract

A novel series of DHODH inhibitors was developed based on a lead which was obtained by a docking procedure and a medicinal chemistry exploration. The activity of the initial lead was improved by a QSAR method to yield low nanomolar inhibitors.

PMID:
14684297
DOI:
10.1016/j.bmcl.2003.10.021
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center