Spatiotemporal dynamics of damped propagation in excitable cardiac tissue

Phys Rev Lett. 2003 Nov 14;91(20):208104. doi: 10.1103/PhysRevLett.91.208104. Epub 2003 Nov 13.

Abstract

Compared to steadily propagating waves (SPW), damped waves (DW), another solution to the nonlinear wave equation, are seldom studied. In cardiac tissue after electrical stimulation in an SPW wake, we observe DW with diminished amplitude and velocity that either gradually decrease as the DW dies, or exhibit a sharp amplitude increase after a delay to become an SPW. The cardiac DW-SPW transition is a key link in understanding defibrillation and stimulation close to the refractory period, and is ideal for a general study of DW dynamics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Electric Stimulation
  • Heart / physiology*
  • Heart Conduction System / physiology*
  • In Vitro Techniques
  • Membrane Potentials / physiology
  • Myocardial Contraction / physiology*
  • Rabbits