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Curr Allergy Asthma Rep. 2004 Jan;4(1):74-82.

Chemokines in eosinophil-associated gastrointestinal disorders.

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  • 1Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, Australia 0200. Simon.Hogan@anu.edu.au

Abstract

Eosinophil-associated gastrointestinal disorders (EGDs) are characterized by a pronounced cellular inflammation. Recent clinical and experimental investigations have implicated a family of molecules known as chemokines in the regulation of leukocyte recruitment in these diseases. The underlying cellular and molecular mechanisms involved in chemokine-mediated cellular infiltration are largely unknown. In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases.

PMID:
14680626
[PubMed - indexed for MEDLINE]
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