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Clin Infect Dis. 2004 Jan 1;38(1):e10-4. Epub 2003 Dec 4.

Autoantibodies to interferon-gamma in a patient with selective susceptibility to mycobacterial infection and organ-specific autoimmunity.

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Department of Clinical Immunology and Biochemistry, Addenbrooke's Hospital, Cambridge, United Kingdom.

Erratum in

  • Clin Infect Dis. 2004 Feb;38(4):602.


We evaluated a patient with disseminated Mycobacterium tuberculosis and Mycobacterium chelonae infection, of which he died. He also developed autoimmune (type I) diabetes and primary hypothyroidism. His serum contained a high titer of immunoglobulin G autoantibody to interferon-gamma (IFN-gamma) capable of blocking in vitro responses to this cytokine by peripheral blood mononuclear cells from normal donors. These results suggest that autoantibodies to IFN-gamma can induce susceptibility to disseminated mycobacterial infection, which may be refractory to chemotherapy.

[Indexed for MEDLINE]

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