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Ann N Y Acad Sci. 2003 Nov;1005:374-7.

Insulin resistance in latent autoimmune diabetes of adulthood.

Author information

1
Lawson Health Research Institute, Robarts Research Institute, London Health Sciences Centre, and St. Joseph's Health Care, University of Western Ontario, London, Ontario, Canada. mbehme@uwo.ca

Abstract

Insulin resistance in patients with latent autoimmune diabetes of adulthood (LADA) was determined by homeostasis model assessment (HOMA). LADA was identified by a clinical phenotype of type 2 diabetes with antibodies to GAD65 and/or IA-2/ICA512. All patients were managed with insulin therapy. Insulin resistance in LADA was lower than in antibody-negative type 2 diabetes, higher than in normal humans and in recent-onset type 1 diabetes, and similar to that in long-term type 1 diabetes. Mean values for HOMA varied linearly with mean values for BMI, which accounted for much of the insulin resistance in these forms of diabetes. LADA resembles long-term type 1 diabetes with respect to insulin resistance and BMI, but occurs at an older age.

PMID:
14679095
DOI:
10.1196/annals.1288.062
[Indexed for MEDLINE]

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