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FEBS Lett. 2003 Dec 18;555(3):631-7.

Differential response of UCP3 to medium versus long chain triacylglycerols; manifestation of a functional adaptation.

Author information

1
Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. j.hoeks@hb.unimaas.nl

Abstract

We compared UCP3 protein in rat cardiac, glycolytic and oxidative skeletal muscle and examined the effect of high-fat medium chain vs. long chain triacylglycerol feeding on UCP3 content in these tissues. Cardiac muscle displays the lowest basal levels of UCP3 protein. Increasing long chain - but not medium chain - fatty acid supply upregulates UCP3 in all muscles. Since plasma non-esterified fatty acids and the expression of two peroxisome proliferator-activated receptor (PPAR)-responsive genes, were not different between groups, we conclude that the differential upregulation of UCP3 is not merely PPAR-mediated. This study supports a role of UCP3 in export of non-metabolizable fatty acids.

PMID:
14675786
DOI:
10.1016/s0014-5793(03)01343-7
[Indexed for MEDLINE]
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