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Cell. 2003 Dec 12;115(6):652-3.

The secret life of ACE2 as a receptor for the SARS virus.

Author information

1
Human Immunovirology and Computational Biology Group, LECB, CCR, NCI-Frederick, NIH, Frederick, MD 21702, USA.

Abstract

The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion.

PMID:
14675530
DOI:
10.1016/s0092-8674(03)00976-0
[Indexed for MEDLINE]
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