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Genetics. 2003 Nov;165(3):1613-7.

Compositional biases and polyalanine runs in humans.

Author information

1
INSERM E0021 and U361, Reproduction et Physiopathologie Obstétricale, Hôpital Cochin, 75014 Paris, France.

Abstract

Human proteins containing polyalanine tracts tend to have runs of other amino acids and their open reading frames (ORFs) display a biased codon usage. Their alanine, glycine, proline, and histidine content strongly correlates with the GC content of the third codon base, suggesting that the compositional specificity of these proteins is dictated to a great extent by the evolution of their ORFs.

PMID:
14668408
PMCID:
PMC1462819
[Indexed for MEDLINE]
Free PMC Article

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