Format

Send to

Choose Destination
Exp Diabesity Res. 2003 Oct-Dec;4(4):213-24.

The role of the insulin-like growth factors and their binding proteins in glucose homeostasis.

Author information

1
Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. ljmurph@cc.umanitoba.ca

Abstract

The insulin like growth factors (IGF-I and -II) are structurally and functionally related to insulin. While insulin is a key regulator of glucose homeostasis over the short term, emerging evidence suggests that the IGFs are involved in the longer term glucose homeostasis, possibly by modulating insulin sensitivity. Unlike insulin, the IGFs are present in most biological fluids as complexes with high affinity binding proteins, the insulin-like growth factor binding proteins (IGFBPs). The IGFBPs regulate the bioavailability of the IGFs. Of the six IGFBPs identified there is evidence from studies in transgenic mice that both IGFBP-1 and IGFBP-3 may have a role in glucose regulation.

PMID:
14668045
PMCID:
PMC2478614
DOI:
10.1155/EDR.2003.213
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center