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Anticancer Res. 2003 Sep-Oct;23(5A):3971-7.

Distinct site-specific oncoprotein overexpression in head and neck squamous cell carcinoma: a tissue microarray analysis.

Author information

1
Deutsches Krebsforschungszentrum, Abt. Molekulare Genetik (H0700), TP3, D-69120 Heidelberg, Germany.

Abstract

BACKGROUND:

Tissue microarray (TMA) analysis is a high-throughput approach that allows the screening of large tumor collectives for cytogenetic aberrrations. In this study, a TMA of a large collection of clinically well-defined primary squamous cell carcinomas of the head and neck (HNSCC) was used to determine the expression of several oncoproteins.

MATERIALS AND METHODS:

A TMA containing 547 primary HNSCC was used for the analysis of cyclinD1, c-myc, erbb1 and erbb2 expression by immunohistochemistry (IHC).

RESULTS:

CyclinD1 and c-myc were overexpressed at higher frequencies in primary pharyngeal and laryngeal carcinomas compared with primary oral carcinomas (p < 0.001 and p < 0.001), while erbb1 and erbb2 overexpression was associated with oral site (p < 0.001 and p = 0.04, respectively). Furthermore, cyclinD1 overexpression correlated with stage IV primary carcinomas (p = 0.04).

CONCLUSION:

HNSCC is a heterogenous group of tumors, which, depending on anatomic sites and clinical stage, shows variable expressions of the oncoproteins described. This indicates a specific pathogenic role of these oncoproteins in different subtypes of HNSCC and may have therapeutic implications.

PMID:
14666705
[Indexed for MEDLINE]

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