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J Neural Transm (Vienna). 2003 Dec;110(12):1401-11. Epub 2003 Oct 24.

Homocysteinemia in psychiatric disorders: association with dementia and depression, but not schizophrenia in female patients.

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Department of Psychiatry and Psychotherapy, Julius-Maximilians-University W├╝rzburg, Germany.


Homocysteinemia has been reported to be a risk factor for dementia, depression and also schizophrenia, the latter in a gender-specific manner. We have determined homocysteine in female inpatients suffering from various psychiatric diseases to further investigate a possible association between homocysteinemia and psychiatric disorders. Homocysteine was not elevated in schizophrenic females (mean, 11.6+/-5.8 micromol/l); in accordance with previous studies, homocysteinemia could be found frequently in dementia of different aetiology (mean, 17.2+/-6.7 micromol/l), but also to a slighter extent in depressive disorders (mean, 12.9+/-3.8 micromol/l), especially in elderly subjects. We thus suggest that homocysteinemia, at least in females, is an unspecific risk factor for organic brain disorders, but not endogenous psychoses.

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