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J Urol. 2004 Jan;171(1):431-3.

Germline mutation analysis of the androgen receptor gene in Finnish patients with prostate cancer.

Author information

1
Department of Clinical Genetics and laboratory of Cancer Genetics, University of Tampere, Tampere University Hospital, Finland. blpako@uta.fi

Abstract

PURPOSE:

Steroid hormones, particularly androgens, are suspected to have a major role in prostate carcinogenesis. Since androgen receptor mediates androgenic effects on cells and recent studies suggest that the androgen receptor gene is a putative prostate cancer susceptibility locus, we screened the coding region of the androgen receptor gene for germline mutations using the genomic DNA of patients with prostate cancer.

MATERIALS AND METHODS:

DNA samples from 38 patients with early onset prostate cancer and 36 from Finnish prostate cancer families showing no male-to-male transmission of prostate cancer were analyzed for mutations in the androgen receptor gene using single strand conformation polymorphism analysis and subsequent sequencing.

RESULTS:

R726L substitution in the hormone binding region of androgen receptor was found in 1 prostate cancer family but no previously uncharacterized germline mutations were detected.

CONCLUSIONS:

Our results indicate that constitutional androgen receptor mutations explain only a small fraction of familial and early onset prostate cancer cases in Finland.

[Indexed for MEDLINE]

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