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Genes Dev. 2003 Dec 1;17(23):2966-78.

Senseless acts as a binary switch during sensory organ precursor selection.

Author information

1
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA.
2
Baylor Coll Med, Houston, TX

Abstract

During sensory organ precursor (SOP) specification, a single cell is selected from a proneural cluster of cells. Here, we present evidence that Senseless (Sens), a zinc-finger transcription factor, plays an important role in this process. We show that Sens is directly activated by proneural proteins in the presumptive SOPs and a few cells surrounding the SOP in most tissues. In the cells that express low levels of Sens, it acts in a DNA-binding-dependent manner to repress transcription of proneural genes. In the presumptive SOPs that express high levels of Sens, it acts as a transcriptional activator and synergizes with proneural proteins. We therefore propose that Sens acts as a binary switch that is fundamental to SOP selection.

PMID:
14665671
PMCID:
PMC289154
DOI:
10.1101/gad.1122403
[Indexed for MEDLINE]
Free PMC Article

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