Format

Send to

Choose Destination
See comment in PubMed Commons below
J Soc Gynecol Investig. 2003 Dec;10(8):490-5.

5-hydroxytryptamine and thromboxane A2 as physiologic mediators of human umbilical artery closure.

Author information

1
Department of Pharmacology, The University of Hong Kong, 21 Sassoon Road, Hong Kong SAR, China.

Abstract

OBJECTIVE:

This study investigated the response of the human umbilical artery to various agonists in order to determine which agents might be involved in umbilical cord closure.

METHODS:

Umbilical artery rings from 22 cesarean deliveries were suspended in tissue baths containing Krebs-Henseleit solution under low and normal oxygen conditions. Samples were challenged with 5-hydroxytryptamine, acetylcholine, angiotensin II, bradykinin, endothelin-1, histamine, norepinephrine, phenylephrine, and U46619 (a thromboxane A(2) mimetic).

RESULTS:

Only 5-hydroxytryptamine, bradykinin, endothelin-1, histamine, and U46619 produced appreciable maximal contractions. Furthermore, although the contractile force generated by these agonists was diminished in normal oxygen conditions, this reduction affected responses to 5-hydroxytryptamine and U46619 least.

CONCLUSION:

5-Hydroxytryptamine and U46619 demonstrated the characteristics most likely to be associated with closure of the umbilical artery, ie, they elicited strong, sustained contractions at physiologic concentrations and under both normal and low-oxygen conditions. These data suggest that closure of the umbilical artery may be mediated by 5-hydroxytryptamine and thromboxane A(2).

PMID:
14662162
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center