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Nat Biotechnol. 2004 Jan;22(1):53-4. Epub 2003 Dec 7.

Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells.

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  • 1Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

Abstract

We have observed karyotypic changes involving the gain of chromosome 17q in three independent human embryonic stem (hES) cell lines on five independent occasions. A gain of chromosome 12 was seen occasionally. This implies that increased dosage of chromosome 17q and 12 gene(s) provides a selective advantage for the propagation of undifferentiated hES cells. These observations are instructive for the future application of hES cells in transplantation therapies in which the use of aneuploid cells could be detrimental.

PMID:
14661028
DOI:
10.1038/nbt922
[PubMed - indexed for MEDLINE]
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