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J Clin Invest. 2003 Dec;112(11):1626-32.

Quorum sensing and biofilm formation in Streptococcal infections.

Author information

1
Room 449A, Dental Research Institute, University of Toronto, 124 Edward Street, Toronto, Ontario M5G 1G6, Canada. dennis.cvitkovitch@utoronto.ca

Abstract

Members of the bacterial genus Streptococcus are responsible for causing a wide variety of infections in humans. Many Streptococci use quorum-sensing systems to regulate several physiological properties, including the ability to incorporate foreign DNA, tolerate acid, form biofilms, and become virulent. These quorum-sensing systems are primarily made of small soluble signal peptides that are detected by neighboring cells via a histidine kinase/response regulator pair.

PMID:
14660736
PMCID:
PMC281653
DOI:
10.1172/JCI20430
[Indexed for MEDLINE]
Free PMC Article

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