Format

Send to

Choose Destination
Cell Cycle. 2004 Jan;3(1):61-3.

Why do cells require heat shock proteins to survive heat stress?

Author information

1
Department of Biochemistry, Sciences II, 30 quai E. Ansermet, CH-1211 Geneva 4, Switzerland. Howard.Riezman@biochem.unige.ch

Abstract

The cellular response to heat stress includes the induction of a group of proteins called the Heat Shock Proteins, whose functions include the synthesis of the thermoprotectant trehalose, refolding of denatured proteins, and ubiquitin- and proteasome-dependent degradation. Recent studies show that simply increasing the activity of ubiquitin- and proteasome-dependent degradation can replace the essential functions played by the induction of heat shock proteins during a heat stress. These results suggest that accumulation of denatured or aggregated proteins is the reason for the loss of cell viability due to heat stress.

PMID:
14657667
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center