Format

Send to

Choose Destination
Stroke. 2004 Jan;35(1):12-5. Epub 2003 Dec 4.

Inflammation, homocysteine, and vitamin B6 status after ischemic stroke.

Author information

1
Stroke Service, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Fruit St, Boston, Mass 02114, USA. pjkelly@partners.org

Abstract

BACKGROUND AND PURPOSE:

Epidemiological studies have described an association between low vitamin B6 (measured as pyridoxal 5'-phosphate [PLP]) and ischemic stroke, independent of homocysteine (tHcy). We investigated B6 status, tHcy, and inflammation (measured by C-reactive protein [CRP]) in patients with stroke and controls.

METHODS:

Consecutive cases with new ischemic stroke were compared with matched controls. Fasting tHcy, PLP, and CRP were measured.

RESULTS:

The adjusted odds ratio of low PLP in the highest compared with the lowest CRP quartile was 16.6 (2, 139.9, P=0.01). Age, CRP, supplemental vitamin use, and albumin were independent predictors of PLP (P<0.05 for all). No relationship was observed between CRP and tHcy.

CONCLUSIONS:

The relationship between inflammation and low B6 status may partially explain the findings of previous epidemiological studies.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center