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Am J Med. 2003 Dec 1;115(8):601-5.

Increased plasma levels of lipoprotein(a) and the risk of idiopathic and recurrent venous thromboembolism.

Author information

1
Dipartimento Area Critica Medico-Chirurgica, Clinica Medica Generale e Cardiologia, Florence, Italy.

Abstract

PURPOSE:

Elevated lipoprotein(a) [Lp(a)] levels are a recognized risk factor for cardiovascular disease; however, little is known about their effects on venous thromboembolism.

METHODS:

We conducted a case-control study of 603 adult patients with a history of venous thromboembolism (at least 6 months after the acute event) and 430 healthy subjects. We measured Lp(a), homocysteine, and antithrombin levels, factor V Leiden and factor II (prothrombin) polymorphisms, and anticardiolipin antibodies.

RESULTS:

Lp(a) levels >300 mg/L were found in 24% (n = 146) of the patients and in 13% (n = 58) of the controls (P = 0.005). In a multivariate analysis adjusted for acquired and hemostasis-related risk factors, there was an independent association between elevated (>300 mg/L) Lp(a) levels and venous thromboembolism (odds ratio = 2.1; 95% confidence interval: 1.4 to 3.2; P = 0.002). These results were confirmed in the 341 patients with idiopathic venous thromboembolism, as well as in those with recurrent thromboembolism.

CONCLUSION:

These results show that Lp(a) is an independent risk factor for venous thromboembolism in adults, suggesting that it may be involved in the pathogenesis of idiopathic and recurrent disease.

PMID:
14656611
DOI:
10.1016/j.amjmed.2003.06.005
[Indexed for MEDLINE]

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