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Scand J Infect Dis. 1992;24(5):629-32.

Antibody response to a Haemophilus influenzae type b polysaccharide tetanus toxoid conjugate vaccine in splenectomized children and adolescents.

Author information

1
Paediatric Department GGK, Rigshospitalet, Copenhagen, Denmark.

Abstract

20 children and adolescents 4-18 years old and splenectomized for various reasons (spherocytosis (n = 6), idiopathic thrombocytopenia (n = 8), other (n = 6)) were immunized once with a Haemophilus influenzae type b (Hib) polysaccharide tetanus toxoid conjugate vaccine. Prior to vaccination 10/20 patients had anticapsular antibodies below what could be considered the minimum protective level in splenectomized (0.6 micrograms/ml), whereas all obtained high antibody levels after vaccination. In addition 1 infant with congenital asplenia was vaccinated at 2,4 and 6 months of age, and was shown to respond well after the second and third injection with serum antibody concentrations of 0.84 and 10.7 micrograms/ml respectively. Because asplenic individuals have an increased risk of invasive Hib infection, these data suggest that vaccination of such individuals against Hib may be justified.

PMID:
1465581
DOI:
10.3109/00365549209054649
[Indexed for MEDLINE]

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