Format

Send to

Choose Destination
See comment in PubMed Commons below
Semin Gastrointest Dis. 2003 Jul;14(3):112-27.

The changing epidemiology of esophageal adenocarcinoma.

Author information

1
Division of Digestive Disease and Nutrition, and the Center for Gastrointestinal Biology and Disease, the University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7080, USA.

Abstract

The incidence of esophageal adenocarcinoma has risen rapidly over the past 3 decades. This increase had been most dramatic among white men. It has supplanted squamous cell carcinoma as the predominant histologic type of esophageal cancer in the United States. The reasons underlying this phenomenon are not readily apparent. Improvements in diagnostic techniques and changes in cancer classification may explain some of the rise in reported incidence rates, but detection bias and misclassification bias do not appear adequate to explain the increase entirely. Risk factors for esophageal adenocarcinoma are reviewed, with particular emphasis on their role in underlying the rising cancer incidence. The etiologic factors most likely to explain the current epidemic of esophageal adenocarcinoma are the parallel epidemic of obesity, rising use of lower esophageal sphincter-relaxing medications, decreasing Helicobacter pylori infection, changes in the Western diet, and distant smoking habits.

PMID:
14653411
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center