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Ann Hematol. 2004 Jun;83(6):394-7. Epub 2003 Nov 27.

Combination therapy of disseminated Fusarium oxysporum infection with terbinafine and amphotericin B.

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Klinik I für Innere Medizin, Universität zu Köln, Joseph-Stelzmann-Str. 9, 50931 Cologne, Germany.


A case of disseminated infection with Fusarium oxysporum following chemotherapy of acute myelogenous leukemia is reported. Antifungal treatment was successful with a 13-day course of oral terbinafine 250 mg t.i.d. in combination with amphotericin B deoxycholate 1.0-1.5 mg/kg qd and subsequently intravenous liposomal amphotericin B 5 mg/kg qd. Preceding monotherapy with amphotericin B deoxycholate 1.0-1.5 mg/kg qd had not stopped the progression of infection. The combination therapy described here represents a novel approach to the treatment of Fusarium spp. in the immunocompromised host in whom Fusarium spp. are known to cause disseminated infection with high mortality.

[Indexed for MEDLINE]

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