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Nat Cell Biol. 2003 Dec;5(12):1029-33.

The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?

Author information

1
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA. dwolf@hsph.harvard.edu

Abstract

The COP9 signalosome (CSN) is a highly conserved protein complex implicated in diverse biological functions that involve ubiquitin-mediated proteolysis. Paradoxically, conserved enzymatic activities associated with CSN inhibit cullin ubiquitin ligase activity in vitro, whereas mutational analysis suggests that CSN promotes cullin-dependent proteolysis in vivo. This apparent paradox can be resolved in a model that proposes CSN-mediated cullin inhibition is a prerequisite for the proper assembly and maintenance of active cullin ubiquitin ligase complexes.

PMID:
14647295
DOI:
10.1038/ncb1203-1029
[Indexed for MEDLINE]

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