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FEBS Lett. 2003 Dec 4;555(2):250-6.

Caenorhabditis elegans dna-2 is involved in DNA repair and is essential for germ-line development.

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Department of Biochemistry, College of Science, Yonsei University, Seoul 120-749, South Korea.


Caenorhabditis elegans germ cell proliferation and development were severely damaged in second generation dna-2 homozygotes. Even in the first generation, a much higher incidence of aberrant chromosomes in oocytes and resultantly higher embryonic lethality were found vs. wild type, when DNA breaks were induced by gamma-rays or camptothecin. The deficiency of dna-2 in combination with RNA interference on mre-11 gene expression synergistically aggravated germ-line development, especially oocyte formation. These results suggest that C. elegans Dna-2 is involved in a DNA repair pathway paralleling homologous recombination or non-homologous end joining with mre-11 participation.

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