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Curr Opin Cell Biol. 2003 Dec;15(6):763-70.

Live and let die in the intestinal epithelium.

Author information

Centre for Biomedical Genetics, Hubrecht Laboratorium, Koninklijke Nederlandse Akademie van Wetenschappen, Utrecht, The Netherlands.

Erratum in

  • Curr Opin Cell Biol. 2004 Feb;16(1):113.


The intestinal epithelium is a relatively simple developmental system and a prime example of tissue renewal from a source of multipotent stem cells. Throughout adulthood, intestinal epithelial proliferation, cell-fate specification and differentiation are coupled to migration in discrete units known as crypts of Lieberk├╝hn. Physically guided by Eph receptors and their ligands, the ephrins, stem cell progeny transit through the proliferation/differentiation switch, and Notch diversifies their subsequent fates. Wnt signalling appears to control most of these events.

[Indexed for MEDLINE]

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