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Behav Brain Res. 2003 Nov 30;146(1-2):159-65.

The role of the prefrontal cortex in object-place learning: a test of the attribute specificity model.

Author information

1
Department of Psychology, University of Utah, 380 South 1530 East Room 502, Salt Lake City, UT 84112, USA. rpkesner@behsci.utah.edu

Abstract

In order to test an attribute specificity model of prefrontal cortex function, rats with lesions in the prelimbic-infralimbic (PL-IL) or anterior cingulate and precentral (AC-PC) subregions of the medial prefrontal cortex and controls were trained on an object-place paired associate task. Rats with AC-PC lesions acquired the task as readily as controls. In contrast, the PL-IL lesioned rats did not learn the task. Whenever higher order processing is required to solve a task, the data support an attribute-specificity model of prefrontal cortex function in that the PL-IL cortices support both object and place attribute information in a variety of tasks including object-place paired associate learning.

PMID:
14643468
DOI:
10.1016/j.bbr.2003.09.024
[Indexed for MEDLINE]

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