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Epilepsia. 2003;44 Suppl 12:30-43.

Toward a neurodynamical understanding of ictogenesis.

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LENA (Laboratoire de Neurosciences Cognitives et Imagerie Cérébrale), CNRS UPR 640, Hôpital de la Pitié-Salpêtrière, 47 Boulevard de l'Hôpital, 75651 Paris cedex 13, France.


Although considerable information on cellular and network mechanisms of epilepsy exists, it is still not understood why, how, and when the transition from interictal to ictal state takes place. The authors review their work on nonlinear EEG analysis and provide consistent evidences that dynamical changes in the neural activity allows the characterization of a preictal state several minutes before seizure onset. This new neurodynamical approach of ictogenesis opens new perspectives for studying the basic mechanisms in epilepsy as well as for possible therapeutic interventions.

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