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Acta Ophthalmol Scand. 2003 Dec;81(6):611-3.

Corneal penetration of levofloxacin into the human aqueous humour: a comparison with ciprofloxacin.

Author information

1
Department of Ophthalmology, Hôpital Pellegrin, Bordeaux, France. joseph.colin@chu-bordeaux.fr

Abstract

PURPOSE:

To compare aqueous humour levels of levofloxacin and ciprofloxacin following topical application to patients scheduled for cataract surgery.

METHODS:

A total of 59 patients undergoing cataract surgery were randomly assigned to topical treatment with either levofloxacin 0.5% or ciprofloxacin 0.3% eye drops, at one drop every 15 min for four doses immediately prior to surgery. Aqueous humour samples were collected by paracentesis and analysed for drug content.

RESULTS:

The (geometric) mean aqueous humour concentration of levofloxacin was 0.728 microg/ml; that of ciprofloxacin was 0.080 microg/ml.

CONCLUSIONS:

Levofloxacin achieves 9.1 times the aqueous humour concentration of ciprofloxacin. It could be considered a better choice than ofloxacin or ciprofloxacin for topical ophthalmic use.

PMID:
14641263
[Indexed for MEDLINE]
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