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J Agric Food Chem. 2003 Dec 3;51(25):7287-91.

Buckwheat concentrate reduces serum glucose in streptozotocin-diabetic rats.

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Department of Human Nutritional Sciences, University of Manitoba, H505 Duff Roblin Building, 190 Dysart Road, Winnipeg, Manitoba, Canada R3T 2N2.


The antihyperglycemic effects of chemically synthesized d-chiro-inositol (d-CI), a component of an insulin mediator, have been demonstrated in rats. Buckwheat contains relatively high levels of d-CI: thus, it has been proposed as a source of d-CI for reducing serum glucose concentrations in diabetics. The present study evaluates the effects of a buckwheat concentrate, containing d-CI, on hyperglycemia and glucose tolerance in streptozotocin (STZ) rats. In fed STZ rats, both doses of the buckwheat concentrate (containing 10 and 20 mg of d-CI/kg of body weight) were effective for lowering serum glucose concentrations by 12-19% at 90 and 120 min after administration. Findings from this study demonstrate that a buckwheat concentrate is an effective source of d-CI for lowering serum glucose concentrations in rats and therefore may be useful in the treatment of diabetes.

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