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Mov Disord. 2003 Nov;18(11):1385-6.

Interleukin-1A (-889) genetic polymorphism increases the risk of multiple system atrophy.

Author information

1
Neurology Service, University Hospital Marqués de Valdecilla, University of Cantabria, Santander, Spain. combarro@unican.es

Abstract

In a case-control study using a clinically well-defined group of 30 multiple system atrophy (MSA) patients and 110 control subjects, homozygosity for interleukin-1A (IL-1A) allele 2 (high secretor of proinflammatory cytokine) in the regulatory region (-889) of the IL-1A gene was associated with a fivefold increased risk for MSA.

PMID:
14639688
DOI:
10.1002/mds.10540
[Indexed for MEDLINE]

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