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Nat Immunol. 2003 Dec;4(12):1169-76.

Suppressors of cytokine signaling and immunity.

Author information

1
Department of Immunobiology, Research Institute for Biological Sciences, Tokyo University of Science, Noda 278-0022, Japan.

Abstract

The suppressors of cytokine signaling (SOCS) and cytokine-inducible SH2 protein are key physiological regulators of the immune system. Principally, SOCS1 and SOCS3 regulate T cells as well as antigen-presenting cells, including macrophages and dendritic cells. Here we review the function of SOCS1 and SOCS3 in innate and adaptive immunity, with particular emphasis on the relationship between immune regulation and SOCS.

PMID:
14639467
DOI:
10.1038/ni1012
[Indexed for MEDLINE]
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