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Clin Biochem. 2003 Nov;36(8):629-32.

Influence of anticoagulants on the measurement of S100B protein in blood.

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  • 1Departamento de Bioquímica, ICBS, UFRGS, Brazil.

Abstract

OBJECTIVE:

Evaluate anticoagulants influence on blood S100B levels.

DESIGN AND METHODS:

Blood from 18 healthy adult subjects were collected using: no anticoagulants; EDTA; heparin; and citrate. S100B levels were determined using LIA-mat assay.

RESULTS:

Heparin and citrate increased S100B levels (p<0.001), whereas EDTA had no effect (p=0.24). Heparin samples were highly (r2=0.97, p<0.001), citrate samples were moderately (r2=0.49, p<0.001), and EDTA samples were not (r2=0.22, p=0.059) correlated with serum samples.

CONCLUSION:

When anticoagulant is required, heparin should be the primary choice.

PMID:
14636878
[PubMed - indexed for MEDLINE]
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