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Adv Exp Med Biol. 2003;536:163-9.

Mitochondrial complex II is essential for hypoxia-induced ROS generation and vasoconstriction in the pulmonary vasculature.

Author information

1
Institute for Anatomy and Cell Biology, Justus-Liebig-University, 35385 Giessen, Germany.

Abstract

Hypoxia induces an increase in the ROS generation by cells of small intrapulmonary vessels. Based on our results we suppose that this is caused by a switch in the catalytic activity of mitochondrial complex II from succinate dehydrogenase to fumarate reductase. Functional complex II is also necessary for hypoxic pulmonary vasoconstriction.

PMID:
14635663
DOI:
10.1007/978-1-4419-9280-2_21
[Indexed for MEDLINE]

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