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Nat Rev Genet. 2003 Nov;4(11):916-23.

Clues to catastrophic telomere loss in mammals from yeast telomere rapid deletion.

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1
Arthur J. Lustig is at the Department of Biochemistry in the Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA. alustig@tulane.edu

Abstract

Catastrophic losses of telomeric sequences have recently been described during apoptosis, senescence and tumorigenesis in murine and human cells, in ataxia telangiectasia patients and in immortalized cells in which telomerase is inactive. A mechanism that underlies a single-step non-reciprocal telomere deletion called telomere rapid deletion in Saccharomyces cerevisiae might provide clues for future studies of catastrophic telomere loss in higher eukaryotes.

PMID:
14634639
DOI:
10.1038/nrg1207
[Indexed for MEDLINE]
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