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Res Commun Mol Pathol Pharmacol. 2002;111(1-4):139-51.

Supplementing with beta-hydroxy-beta-methylbutyrate (HMB) to build and maintain muscle mass: a review.

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Department of Physiology, Medicine and Pathology, Georgetown University Medical Center, Washington, DC 20057, USA.


Beta-hydroxy-beta-methylbutyrate, more commonly referred to as HMB, is derived from the amino acid, leucine, and its keto acid, alpha-ketoisocaproate. In several studies combining HMB supplementation and resistance exercise, researchers have concluded that HMB may play an important role in reducing protein degradation and/or increasing recovery of damaged muscle cells. These actions could be advantageous to all individuals participating in exercise programs and improve the lives of many by overcoming weakness or frailty.

[Indexed for MEDLINE]

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