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Biochem J. 2004 Feb 15;378(Pt 1):213-7.

Mitochondrial cytochrome c release may occur by volume-dependent mechanisms not involving permeability transition.

Author information

1
Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden.

Abstract

The mechanisms regulating mitochondrial outer-membrane permeabilization and the release of cytochrome c during apoptosis remain controversial. In the present study, we show in an in vitro model system that the release of cytochrome c may occur via moderate modulation of mitochondrial volume, irrespective of the mechanism leading to the mitochondrial swelling. In contrast with mitochondrial permeability transition-dependent release of cytochrome c, in the present study mitochondria remain intact and functionally active.

PMID:
14629197
PMCID:
PMC1223940
DOI:
10.1042/BJ20031193
[Indexed for MEDLINE]
Free PMC Article

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