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Agents Actions Suppl. 1992;38 ( Pt 3):110-8.

The effect of bradykinin on coronary flow and its potentiation by SH-containing ACE-inhibitors.

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1
Department of Pharmacology/Clinical Pharmacology, University of Groningen, The Netherlands.

Abstract

Bradykinin plays a role in the regulation of coronary blood flow. Under basic conditions the vasodilating effect is primarily mediated by stimulation of the endogenous nitrovasodilator endothelium-derived relaxing factor (EDRF). This effect is shortlasting but can be increased and prolonged by sulfhydryl(SH)-containing agents. ACE-inhibitors may cause coronary vasorelaxation by a bradykinin-mediated release of EDRF. This can be potentiated by the presence of SH-groups, as was shown with captopril and zofenoprilat. As a consequence, SH-containing ACE-inhibitors may potentiate nitrates, because they act as exogenous nitrovasodilators, and reverse tolerance to their therapeutic effect.

PMID:
1462853
[Indexed for MEDLINE]
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