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Dig Dis Sci. 2003 Oct;48(10):2077-82.

A randomized trial of yogurt for prevention of antibiotic-associated diarrhea.

Author information

1
Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Roudebush VA Medical Center, (11H) 1481 W. 10th Street, Indianapolis, Indiana 46202, USA. rbeniwal@iupui.edu

Abstract

Antibiotic-associated diarrhea (AAD) is the most common adverse effect of antibiotic therapy. Our aim was to determine the effectiveness of a dietary supplement of yogurt for prevention of AAD. Two hundred two hospitalized patients receiving oral or intravenous antibiotics were randomized to receive or not receive a dietary yogurt supplement, consisting of 227 grams of commercial yogurt, and followed for 8 days. Mean age of the study group was 70 years and 43% were male. Compliance and 8-day follow-up were 85% and 91%, respectively. Patients receiving yogurt reported less frequent diarrhea (12% vs 24%; P = 0.04), and significantly less total diarrhea] days (23 vs 60). The cumulative proportions of patients without diarrhea were significantly different (P = 0.02) between patients receiving and not receiving yogurt. For conclusion, dietary supplementation with yogurt is a simple, effective, and safe treatment that decreases the incidence and duration of AAD.

PMID:
14627358
[Indexed for MEDLINE]

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