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Neuroreport. 2003 Dec 2;14(17):2209-11.

Exercise activates the endocannabinoid system.

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1
School of Applied Physiology, Georgia Institute of Technology, Atlanta, GA 30332, USA.

Abstract

Extensive documentation exists showing that exercise induces analgesia and sedation. Despite decades of research attempting to explicate a neurochemical basis for these phenomena, the mechanism underlying these changes is unknown. Using trained male college students running on a treadmill or cycling on a stationary bike for 50 min at 70-80% of maximum heart rate, we report here the first evidence that exercise of moderate intensity activates the endocannabinoid system, suggesting a new mechanism for exercise-induced analgesia and possibly other physiological and psychological adaptations to exercise.

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