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Biol Psychiatry. 2003 Nov 15;54(10):1025-34.

Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys.

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1
Harlow Primate Laboratory (CLC), University of Wisconsin, Madison, Wisconsin, USA

Abstract

BACKGROUND:

Early life stress, including during fetal development, has been hypothesized to predispose individuals to several illnesses and psychiatric disorders later in adulthood.

METHODS:

To determine whether prenatal stress alters neural, hormonal, and behavioral processes in nonhuman primates, pregnant rhesus monkeys were acutely stressed on a daily basis for 25% of their 24-week gestation with an acoustical startle protocol. At 2 to 3 years of age, hippocampal volume, neurogenesis in the dentate gyrus, and cortisol levels were evaluated in the offspring generated from stressed and control pregnancies.

RESULTS:

Prenatal stress, both early and late in pregnancy, resulted in a reduced hippocampal volume and an inhibition of neurogenesis in the dentate gyrus. These changes were associated with increased pituitary-adrenal activity, as reflected by higher cortisol levels after a dexamethasone suppression test, and also with behavioral profiles indicative of greater emotionality.

CONCLUSIONS:

These findings indicate that the prenatal environment can alter behavior, dysregulate neuroendocrine systems, and affect the hippocampal structure of primates in a persistent manner.

PMID:
14625144
[Indexed for MEDLINE]
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