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Steroids. 2003 Oct;68(9):733-8.

Synthesis of deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids.

Author information

1
Dipartimento di Scienze Precliniche LITA Vialba, Universit√° degli Studi di Milano, Via G.B. Grassi, 74-20157, Milan, Italy.

Abstract

Deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids formation from cholesterol, were prepared from [2,2,3,4,4,6-2H(6)]-cholesterol and (20S)-[7,7,21,21-2H(4)]-3beta-(tert-butyldimethylsilyl)oxy-20-methylpregna-5-en-21-ol, respectively.

PMID:
14625005
DOI:
10.1016/s0039-128x(03)00116-8
[Indexed for MEDLINE]

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