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J Infect Dis. 2003 Nov 15;188(10):1605-9. Epub 2003 Oct 23.

Oral administration of beta-lactamase preserves colonization resistance of piperacillin-treated mice.

Author information

1
Division of Infectious Diseases, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA. curtisd123@yahoo.com

Abstract

We hypothesized that orally administered, recombinant class A beta-lactamase would inactivate the portion of parenteral piperacillin excreted into the intestinal tract, preserving colonization resistance of mice against nosocomial pathogens. Subcutaneous piperacillin or piperacillin plus oral beta-lactamase were administered 24 and 12 h before orogastric inoculation of piperacillin-resistant pathogens. Oral administration of beta-lactamase reduced piperacillin-associated alteration of the indigenous microflora and prevented overgrowth of pathogens.

PMID:
14624388
DOI:
10.1086/379153
[Indexed for MEDLINE]

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